A small study pairing Talquetamab with Daratumamab on heavily pre-treated patientseven patients whod already had BCMA targeted therapies (both CAR Tand BlenRep)even patients refractory to CD38 targeted therapy (daratumamab)showed efficacy similar to the single agent study! Krina Patel, MD, MSc, discusses research and initiatives that may help to mitigate disparities in patients with multiple myeloma including factors such as gender, race, and ethnicity. 5. The new exclusion criteria could represent an incremental headwind for Bluebird should it get to market, wrote SVB Securities analyst Mani Foroohar. I just get excited when I attend ASH and I see so many stellar people doing what seem to be super-human things by coming up with these life-lengthening miracles that just might possibly keep me alive until theres a cure. The latest R&D info about Janssen-Cilag Ltd.: pipelines, patents If you . It seems the total effect is a real drying effect. Talquetamab (JNJ-64407564) is a bispecific IgG4 antibody that redirects T-cell killing to multiple myeloma cells by binding to the novel target, GPRC5D, and CD3. With talquetamab, only about half the patients make it to only a little more than a year before they relapse. Thus, combination therapies may both enhance activity and offer a favorable side-effect profile. Talquetamab is an IgG4 Fc-containing BsAb targeting G- protein-coupled receptor family C group 5 member D . And a new kind of drug from Argenx was included in the meetings highlights, with updated results detailing another potential use of the biotechnology companys medicine. Epub 2022 Dec 11. Ac., CYT, Enzalutamide, combined with standard treatment, shows promise in prostate cancer, What to know about endometrial stromal sarcoma. In June 2022, the FDA granted talquetamab a breakthrough therapy designation.3. And this particular study showed us a bit more mature, larger number, patient data of talquetamab in patients with relapsed/refractory myeloma. Trimm 2 Study - Multiple Myeloma Clinical Trials In addition to various side effects including Cytokine Release Syndrome (SRS) which are seen in many targeted therapies, Talquetamab causes some skin related and nail disorder adverse eventsin 75% of patientsAll of the noted side effects, however, were considered manageable and reversible. NS-001. Their findings were published as a case study in Nature Medicine in December. Would you like email updates of new search results? At the data-cutoff date, 232 patients had received talquetamab (102 intravenously and 130 subcutaneously). Failure of CAR-T cell therapy in relapsed and refractory large cell If you follow a few myelomagroups on Facebook you might have seen a really gnarly picture of the hands of a patient in a Talquetamab trial. The response rate observed in the study, which Chari explained is higher than that for most . The fast-advancing pipeline could expand options for multiple myeloma patients, but also raise questions about how treatments should be sequenced and how future drug trials might best be designed. Oncology On-The-Go Podcast: Multiple Myeloma Outcome Disparities, Trial Access. The response rate observed in this cohort, which Dr. Chari explained is higher than that of most currently accessible therapies, suggests talquetamab could offer a viable option for patients with hard-to-treat myeloma, offering a chance to extend patient . A standardized regimen of topical and oral supportive care appears to be beneficial in the management of . Following treatment with the immunotherapy drug in the Mount Sinai Health System trial, almost three-quarters of the participants showed improvement, with 30% having a complete response to the drug. No other study participants in the trial had the same genotype. Off-the-shelf Immune Drug for Aggressive Multiple Myeloma: Teclistamab We've talked about this, but just to . We need options for those patients, said Ajai Chari, a study author and hematologist from the Tisch Cancer Institute at Mount Sinai in New York, in a press conference held by ASH. Teclistamab (Tecvayli) for the Treatment of Multiple Myeloma MonumenTAL-1 trial Shows Promise With Talquetamab in R/R Myeloma Side effects, CRS, but also I wanted to point out, unique to this target, we also saw nail toxicity, because GRC5D is expressed on keratinized tissue, also dysgeusia, which, which is a little . Endometrial stromal sarcoma (ESS) is a rare form of uterine cancer that typically affects people during or after menopause. But neither are expected to give the cash-strapped company significant revenue, making a third program for sickle cell disease crucial to its future. The updated Phase 1 results from the MonumenTAL study found that Talquetamab is well tolerated and highly effective at both recommended Phase 2 doses. SGO 2023 Annual Meeting on Womens Cancer, FDA Approves Polatuzumab Vedotin-piiq Plus R-CHP for Previously Untreated DLBCL Not Otherwise Specified and High-Grade B-Cell Lymphoma, Exercise and Wellness Programs May Enhance Well-Being and Reduce Health-Care Costs in Patients With Breast Cancer, Does Surveillance Mammography Benefit Geriatric Patients With Breast Cancer, Intraoperative vs Postoperative Lymph Node Pathology Evaluation in Patients With Breast Cancer Undergoing Mastectomy, Subcutaneous vs Intravenous Rituximab in First-Line Treatment of LowTumor Burden Follicular Lymphoma. Should it win an OK, talquetamab would join a cell therapy and another, recently cleared bispecific antibody in J&Js portfolio of multiple myeloma treatments. The American Society of Hematologys annual conference is the years biggest stage for the most consequential research in treating blood diseases, attracting doctors, drugmakers and investors eager to vet the latest clinical trial results. The Janssen Pharmaceutical Companies of Johnson & Johnson. Drugs targeting GPRC5D, for instance, could offer an alternative to BCMA-binding treatments. Can this be used for MM treatment? : r/multiplemyeloma With bispecific antibodies, the way we give . . Lots of liquids, smoothies, small bites, [and teaching them to] sit upright when they eat [and] wash everything down with liquidbecause it seems that dryness was just extending all the way down the upper gastrointestinal [GI] tract., A take home is the early treatment of oral candida, she concluded.
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